Coagulation disorders in Covid-19 patients

So far the pathophysiology of infection due to coronavirus 2019 (covid 19) is not well elucidated, however, several studies suggest that there is a link between the coagulation system and Sars-coV2. The objective of this work is to study the variability of coagulation parameters in patients infected with covid-19. Patients and methods: We have collected 102 confirmed Covid 19 infected patients (group 1), hospitalized at the Covid 19 center of the CHU Mohamed VI of Marrakesh, we have studied the coagulation parameters in these patients and comparing them with a group of control patients (group 2) who did not present any coronavirus infection. Results: The mean age was 46 years in group 1 and 40 years in group 2, with male predominance in both groups (55.4% in G1 and 52.8% in G2). D-dimer (1.35±2.1 vs 0.18±0.05, p<0.001) and fibrinogen (4.04 (±1.85) vs 2.13 (±0.308), p <0.001) levels in G1 are elevated relative to G2, while prothrombin levels are decreased (84.7 (±16.9) vs 93.1 (±6.60), p<0.01). We did not observe a significant difference between the two groups with respect to platelet count, International Normalized Ratio (INR) and APTT (p >0.05). D-dimer and fibrinogen values in severe Covid 19 patients were higher than in non-severe Covid 19 patients (p<0.001). Conclusion: Clotting factors in Sars cov 2 patients are significantly impaired compared to those in the control group. The high level of fibrinogen and D-dimer may be a marker for the early identification of severe cases.