Kayakalpam (Rejuvenative) herbs: An immunomodulators in Siddha system of medicine: A scientific review

Background: Kayakalpam (Rejuvenative) medicine is one of the prime treatment technique in the Siddha system of medicine. Kayakalpam has potential to heal, rejuvenate and balance the vatham, pitham and kapam (tri-dhosas) which make the body and mind to attain its stability. Several studies have been done on Kayakalpam medicines, but, this review article states about few Kayakalpam herbs, their chemical constituents, pharmacological activities and its immuno-modulatory mechanism towards the prevention and management of non-communicable diseases and several other diseases.
Methods: A literature review was conducted using the following scientific databases: PubMed, Research gate, Science Direct, Google scholar, Ayurvedic Pharmacopoeia of India and Siddha Pharmacopoeia of India. The aim was to identify published data on traditionally used medicinal plant for rejuvenation and immuno-modulatory effect. From that, few Kayakalpam herbs have been chosen which has been mentioned in the Siddha literature and reviewed its nature.
Conclusion: This literature review reveals the potential effect of Kayakalpam herbs and its nature. Beyond any doubt it will help in prevention and management of non-communicable diseases and several other diseases.