Measurement of coagulation profiles (PT and APTT) among pregnant women with recurrent abortion in Sudan

Background: Abortion is a very serious problem that affects in health and life of many ladies during childbearing, and research in recent years has shown a link between blood clotting and miscarriage, blood clotting poses a danger to the mother and her baby. Hemostatic disorders in abortion are rare, but when they occur, they can lead to serious complications, and increased blood loss is usually due to incomplete abortion, laceration, perforation, or uterine anatomy rather than coagulation disorder. Severe hemorrhage can induce consumptive coagulopathy. Prothrombin time and activated partial thromboplastin time are preliminary tests of coagulation profile to detect Haemostatic disorders, this study aimed to evaluate the coagulation profile PT and APTT in recurrent abortion and if it is useful to determine the incidence of abortion in women.
Methods and Results: This was a case control study conducted in Khartoum state hospitals (Sudan) during the period of June to August (2019) to measure PT and APTT among ladies with recurrent abortion. The study included 100 samples (50 abortion-50 control), and the diagnosis was based on manual methods. The age group for abortion was between 20 to 45 years old, and the mean age was (32.96) years. In < 30 years the frequency of abortion was 19 (38%) and in > 30 years were 31 (62%). The correlation done between age group and abortion was shows significant results (P value 0.003). And also, the correlation between abortion and PT, APTT was highly significant (P value < 0.005). The frequency of abortions that occurred in the first (64%) was higher than second trimester (36%).
Conclusion: The present study demonstrates a highly significant elevation in PT and APTT in the abortion group compared with the normal group and results were affected by age and month of abortion. The results obtain indicated that measurement of PT, APTT were necessary when evaluating female with recurrent miscarriages, seems to be a predictive parameter for miscarriage.