An Ayurvedic intervention in the management of Pramehajanya Upadrava Vis-a-Vis Diabetic Nephropathy with Special reference to Microalbuminuria: A Pilot Study

Diabetes Mellitus is a multifactorial Clinical Syndrome affecting multiple systems and Organs. Type-1 DM is an autoimmune disease Characterized by antibody mediated and cell mediated destruction of pancreatic cells while Type-2 DM is Characterized by relative deficiency and resistance to insulin action. One of the micro vascular Complication of Diabetes mellitus is Diabetic Nephropathy also known as Diabetic Kidney disease (D.K.D.) leading to End Stage Renal disease (E.S.R.D.) in due course of time.
In Ayurveda classical texts, although there is no any direct reference in prameha Chapter of renal complications, but in 'Mutraghata Chapter' few Similar Conditions are explained and hence may be Co- related with nephropathies. The disease prameha happens due to derangement into Tridoshas (three humors) and especially Vata dosha dominance in etiopathogenesis leads to Madhumeha; the nearest Co- relate of D.M.
In the present study pre diagnosed patients of Type-2 D.M were randomly selected and Screened for microalbuminuria levels i.e. the albumin Levels in urine ranging between 30-300 mg/24 hr. urine. An Ayurvedic drug 'Gokshura - Brihatyadi Kashaya' was administered in the dose of 50 ml twice daily for 60 days. The subjective and objective parameters were assessed before Treatment and after completion of 60 days which shows significant reduction in both type of parameters.