Drugs and their potential teratogenic effect: A literature review

When addressing the etymological meaning, the word teratogenesis denotes gross or "monstrous" malformations, it is currently accepted that teratogenesis is related to any defect or alteration of embryo-fetal development, whether at the functional or structural level. In general, for gross structural defects to occur, the noxa or offending substance must act on a specific period of embryonic development, which is usually at the end of the second week from conception and up to approximately 8 weeks after conception. During this critical period, organs are forming, and teratogens can produce malformations that are usually apparent at birth.