Effect of age on procoagulants in people with obesity at Sapele, Southern Nigeria

Background/Objectives: Aged people with obesity are vulnerable to coagulation disorders arising from alterations in procaogulants. Therefore, this study aims to evaluate the effect of age on procaogulant such as: fibrinogen (FG), von willebrand factor (vWF), Soluble Vascular Cell Adhesion Molecules (sVCAM) tissue factor (TF), Tissue Plasminogen Activator (tPA) and Plasminogen Activator Inhibitor (PAI) in obese people.
Materials and Method: 312 subjects with age between 18 and 65years were enrolled for this study comprising of 111males and 201females who were further grouped into age ranges of 20-39years, 40-49years and 50-59years respectively. 4.5mls of venous blood was collected into Ethylene Diamine Tetra-acetic Acid (EDTA) container. Plasma obtained was analyzed using ELISA method.
Results: FG values in obese people within age range 20-29years was 100.59±209.23ng/ml while FG level of people within age range 40-49years and 50-59years were71.14±64.24ng/ml and 41.83±15.63ng/ml respectively at p<0.05. PAI of those within age range of 20-39years was 411.65±349.88pg/ml while PAI of people in age range of 50-59years was 265.92±64.30pg/ml. sVCAM of people in the age range of 20-39years was 8.24±12.61u/l and people within the age range of 50-59years had sVCAM value of 4.42±1.17u/l. TF values of people within the age range of 20-39years was 82.03±54.21pg/ml while people in the age range of 50-59years had TF value of 74.54±20.05pg/ml at P<0.05. vWF of people within age range of 50-59years was 84.88±58.96u/l while younger people in the age range of 20-29years had vWF value of 74.59±55.32u/l at P<0.05.
Conclusion: Procaogulants such as: FG, PAI, sVCAM and TF were higher in younger people than in older people with obesity at Sapele southern Nigeria.