1 Department of Anesthesia and Intensive Care techniques, Faculty of AL tuff College, Karbala, 56001, Iraq.
2 Faculty of Pharmacy, National University of Science and Technology, Nasiriyah, 64001, Iraq.
World Journal of Advanced Research and Reviews, 2022, 14(01), 436–448
Article DOI: 10.30574/wjarr.2022.14.1.0346
DOI url: https://doi.org/10.30574/wjarr.2022.14.1.0346
Received on 17 March 2022; revised on 20 April 2022; accepted on 22 April 2022
The aim of this study to evaluate the expression of Programmed cell death-1 (PD-1), TGF- ß, and IL-10 in placental tissue of aborted women and the correlation with Toxoplasma.gondii (T. gondii) and the correlation of these cytokines with each other and with toxoplasmosis, during an abortion. The placental tissue samples have been processed and used for immunohistochemistry to study the expression of PDL-1, IL-10, and TGF-β. There was an increase in expression of TGF-β, PDL-1, and IL-10 in the placental tissue of aborted women infected with T.gondii, The results of the study showed that the residence of pregnant women in an urban area or rural has no relation with Toxoplasmosis infection (P>0.05), Age shows a significant correlation with Toxoplasmosis, the risk of infection increased with age (P<0.05). The number of recurrent abortions has no significant correlation effect in toxoplasmosis infection and abortion between the positive and control groups (P>0.05), Placental expression of PDL-1, IL-10, and TGF-β show significant correlation during infection with toxoplasmosis (P<0.05).
TGF-β; PDL-1; IL-10; Toxoplasma gondi
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HA Alsailawi, SS Ayat, Mustafa Mudhafar, Ruaa K Mohammed, Sahi J Dhahi, MM Abdulrasool, Shahad Shawkat and Hussein A. Raheem. Immunohistochemical study of TGF-β, PDL-1, and IL-10 in patients with Toxoplasma gondii. World Journal of Advanced Research and Reviews, 2022, 14(01), 436–448. Article DOI: https://doi.org/10.30574/wjarr.2022.14.1.0346
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